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Smad2/3 (Phospho Thr8) (PT0741R) PT® Rabbit mAb
商品貨號： PLR10011
適 應(yīng) 性： 人,小鼠,大鼠
WB IF ELISA IP
￥1200元
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  • 靶點(diǎn)-Target： Smad2/3
  • MW(Calculated)： 48kD
  • MW(Observed)： 62kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 修飾-Modification： Phospho
  • 修飾位點(diǎn)： Thr8
  • 推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0741R
  • 特異性： Phospho-Smad2/3 (T8) Antibody detects endogenous levels of Smad2/3 protein only when phosphorylated at T8.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in 人 samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PFtPP
  • 基因名稱： SMAD2/SMAD3
  • 蛋白名稱： Mothers against decapentaplegic homolog 2/3
  • 別名： SMAD2;MADH2;MADR2;Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2;SMAD3;MADH3;Mothers against decapentaplegic
  • Organism-1： 人
  • 基因ID-1： 4087;4088
  • SwissProt-1： Q15796;P84022
  • Organism-2： Mouse
  • 基因ID-2： 17126;17127
  • Organism-3： Rat
  • 基因ID-3： 29357;25631
  • SwissProt-3： O70436;P84025
  • 細(xì)胞定位： Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
  • 組織表達(dá)： Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Smad2/3 (Phospho Thr8) (PT0741R) PT® Rabbit mAb
Catalog No PLR10011
Product information
  • 靶點(diǎn)-Target： Smad2/3
  • MW(Calculated)： 48kD
  • MW(Observed)： 62kD
  • 宿主物種-Host Species： Rabbit
  • 同種型-Isotype： IgG,Kappa
  • 修飾-Modification： Phospho
  • 修飾位點(diǎn)： Thr8
  • 推薦稀釋比： WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200;
  • 組成： PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
  • 純化工藝： Protein A
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 克隆性： Monoclonal
  • 克隆號： PT0741R
  • 特異性： Phospho-Smad2/3 (T8) Antibody detects endogenous levels of Smad2/3 protein only when phosphorylated at T8.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in 人 samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):PFtPP
  • 基因名稱： SMAD2/SMAD3
  • 蛋白名稱： Mothers against decapentaplegic homolog 2/3
  • 別名： SMAD2;MADH2;MADR2;Mothers against decapentaplegic homolog 2;MAD homolog 2;Mothers against DPP homolog 2;JV18-1;Mad-related protein 2;hMAD-2;SMAD family member 2;SMAD 2;Smad2;hSMAD2;SMAD3;MADH3;Mothers against decapentaplegic
  • Organism-1： 人
  • 基因ID-1： 4087;4088
  • SwissProt-1： Q15796;P84022
  • Organism-2： Mouse
  • 基因ID-2： 17126;17127
  • Organism-3： Rat
  • 基因ID-3： 29357;25631
  • SwissProt-3： O70436;P84025
  • 細(xì)胞定位： Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 (PubMed:9865696, PubMed:21145499). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101, PubMed:19289081). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
  • 組織表達(dá)： Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
    • Hunan UPT Biotechnology Co.,Ltd
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