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TET2 rabbit pAb
商品貨號： PLA021537
適 應(yīng) 性： 人,小鼠
WB IHC
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 基因名稱： TET2 KIAA1546 Nbla00191
  • 蛋白名稱： Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
  • Human_gene_id： 54790
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54790
  • Human_swiss_prot_no： Q6N021
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q6N021/entry
  • Mouse_gene_id： 214133
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=214133
  • Mouse_swiss_prot_no： Q4JK59
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q4JK59/entry
  • 特異性： This antibody detects endogenous levels of TET2 at Human, Mouse
  • 組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000 IHC 1:50-200
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
  • 分子量： 220kD
  • 功能： Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 組織表達(dá)： Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.
  • 科研貨號： PLA021537
TET2 rabbit pAb
Catalog No PLA021537
Product information
  • 基因名稱： TET2 KIAA1546 Nbla00191
  • 蛋白名稱： Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
  • Human_gene_id： 54790
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54790
  • Human_swiss_prot_no： Q6N021
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q6N021/entry
  • Mouse_gene_id： 214133
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=214133
  • Mouse_swiss_prot_no： Q4JK59
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q4JK59/entry
  • 特異性： This antibody detects endogenous levels of TET2 at Human, Mouse
  • 組成： Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000 IHC 1:50-200
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： Methylcytosine dioxygenase TET2 (EC 1.14.11.n2)
  • 分子量： 220kD
  • 功能： Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT.
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 組織表達(dá)： Broadly expressed. Highly expressed in hematopoietic cells; highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.
  • 科研貨號： PLA021537
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