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Retinoic Acid Receptor α/β rabbit pAb
商品貨號(hào)： PLA021479
適 應(yīng) 性： 人,小鼠,大鼠
WB
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 基因名稱： RARA NR1B1
  • 蛋白名稱： Retinoic Acid Receptor α/β
  • Human_gene_id： 5914
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5914
  • Human_swiss_prot_no： P10276
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/P10276/entry
  • Mouse_gene_id： 19401
  • Mouse_gene_link： https://www.uniprot.org/uniprot/19401
  • Mouse_swiss_prot_no： P11416
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P11416
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/0
  • 特異性： This antibody detects endogenous levels of Retinoic Acid Receptor α/β at Human, Mouse,Rat
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
  • 實(shí)測(cè)條帶： 50kD
  • 功能： disease:Chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia (APL) [MIM:612376]. Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.,online information:Retinoic acid receptor entry,PTM:Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with CDK7 (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner.,
  • 細(xì)胞定位： Nucleus . Cytoplasm . Nuclear localization depends on ligand binding, phosphorylation and sumoylation (PubMed:19850744). Translocation to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation (By similarity). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758). .
  • 組織表達(dá)： Expressed in monocytes.
  • 科研貨號(hào)： PLA021479
Retinoic Acid Receptor α/β rabbit pAb
Catalog No PLA021479
Product information
  • 基因名稱： RARA NR1B1
  • 蛋白名稱： Retinoic Acid Receptor α/β
  • Human_gene_id： 5914
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5914
  • Human_swiss_prot_no： P10276
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/P10276/entry
  • Mouse_gene_id： 19401
  • Mouse_gene_link： https://www.uniprot.org/uniprot/19401
  • Mouse_swiss_prot_no： P11416
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/P11416
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/0
  • 特異性： This antibody detects endogenous levels of Retinoic Acid Receptor α/β at Human, Mouse,Rat
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
  • 實(shí)測(cè)條帶： 50kD
  • 功能： disease:Chromosomal aberrations involving RARA may be a cause of acute promyelocytic leukemia (APL) [MIM:612376]. Translocation t(11;17)(q32;q21) with ZBTB16/PLZF; translocation t(15;17)(q21;q21) with PML; translocation t(5;17)(q32;q11) with NPM.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:This is a receptor for retinoic acid. This metabolite has profound effects on vertebrate development. Retinoic acid is a morphogen and is a powerful teratogen. This receptor controls cell function by directly regulating gene expression.,online information:Retinoic acid receptor entry,PTM:Phosphorylated. Phosphorylation does not change during cell cycle. Phosphorylation on Ser-77 is crucial for transcriptional activity.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Interacts with CDK7 (By similarity). Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner.,
  • 細(xì)胞定位： Nucleus . Cytoplasm . Nuclear localization depends on ligand binding, phosphorylation and sumoylation (PubMed:19850744). Translocation to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation (By similarity). Increased nuclear localization upon pulsatile shear stress (PubMed:28167758). .
  • 組織表達(dá)： Expressed in monocytes.
  • 科研貨號(hào)： PLA021479
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