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APOB rabbit pAb
商品貨號(hào)： PLA021314
適 應(yīng) 性： 人,大鼠,小鼠,
WB ELISA
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 基因名稱： APOB
  • 蛋白名稱： APOB
  • Human_gene_id： 338
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=338
  • Human_swiss_prot_no： P04114
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/P04114/entry
  • 特異性： This antibody detects endogenous levels of Human APOB
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:1000-2000 ELISA 1:5000-20000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]
  • 分子量： 502kD
  • 功能： disease:Defects in APOB are a cause of familial hypobetalipoproteinemia (FHBL) [MIM:107730]. FHBL is a genetically heterogeneous autosomal co-dominant disorder, associated with reduced plasma concentrations of apoB, LDL and VLDL. Heterozygotes for FHBL are usually asymptomatic with LDL cholesterol and apoB-100 concentrations less than 50% of those in normal plasma. Homozygotes have extremely low plasma LDL cholesterol and apoB-100 concentrations, and clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia [MIM:200100].,disease:Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.,disease:Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.,function:Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.,online information:Apolipoprotein B entry,online information:The Singapore human mutation and polymorphism database,PTM:Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.,RNA editing:The stop codon (UAA) at position 2180 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL.,similarity:Contains 1 vitellogenin domain.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3328
  • 細(xì)胞定位： Cytoplasm . Secreted . Lipid droplet .
  • 科研貨號(hào)： PLA021314
APOB rabbit pAb
Catalog No PLA021314
Product information
  • 基因名稱： APOB
  • 蛋白名稱： APOB
  • Human_gene_id： 338
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=338
  • Human_swiss_prot_no： P04114
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/P04114/entry
  • 特異性： This antibody detects endogenous levels of Human APOB
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:1000-2000 ELISA 1:5000-20000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： Apolipoprotein B-100 (Apo B-100) [Cleaved into: Apolipoprotein B-48 (Apo B-48)]
  • 分子量： 502kD
  • 功能： disease:Defects in APOB are a cause of familial hypobetalipoproteinemia (FHBL) [MIM:107730]. FHBL is a genetically heterogeneous autosomal co-dominant disorder, associated with reduced plasma concentrations of apoB, LDL and VLDL. Heterozygotes for FHBL are usually asymptomatic with LDL cholesterol and apoB-100 concentrations less than 50% of those in normal plasma. Homozygotes have extremely low plasma LDL cholesterol and apoB-100 concentrations, and clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia [MIM:200100].,disease:Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB) [MIM:144010]. FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.,disease:Defects in APOB associated with defects in other genes (polygenic) can contribute to hypocholesterolemia.,function:Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.,online information:Apolipoprotein B entry,online information:The Singapore human mutation and polymorphism database,PTM:Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.,RNA editing:The stop codon (UAA) at position 2180 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL.,similarity:Contains 1 vitellogenin domain.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3328
  • 細(xì)胞定位： Cytoplasm . Secreted . Lipid droplet .
  • 科研貨號(hào)： PLA021314
    • Hunan UPT Biotechnology Co.,Ltd
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    E-mail：service@uptbio.com
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