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K2C75 rabbit pAb
商品貨號(hào)： PLA021195
適 應(yīng) 性： 人,小鼠,大鼠
WB IHC ELISA
￥600元
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MSDS
說明書
商品描述
  • 基因名稱： KRT75 K6HF KB18
  • 蛋白名稱： K2C75
  • Human_gene_id： 9119
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9119
  • Human_swiss_prot_no： O95678
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/O95678/entry
  • Mouse_gene_id： 109052
  • Mouse_gene_link： https://www.uniprot.org/uniprot/109052
  • Mouse_swiss_prot_no： Q8BGZ7
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8BGZ7
  • Rat_gene_id： 300247
  • Rat_gene_link： https://www.uniprot.org/uniprot/300247
  • Rat_swiss_prot_no： Q6IG05
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q6IG05
  • 特異性： This antibody detects endogenous levels of K2C75 at Human/Mouse/Rat
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 分子量： 61kD
  • 功能： disease:Defects in KRT75 may be a cause of loose anagen hair syndrome (LAHS) [MIM:600628]. In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.,function:Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.,miscellaneous:May be used as a marker of hair differentiation.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,polymorphism:The Thr-161 variant may increase risk to develop pseudofolliculitis barbae (PFB) [MIM:612318]. PFB is a common hair disorder characterized by a pustular foreign body inflammatory reaction that is induced by ingrown hairs of the facial and submental (barbea) regions after regular shaving. It occurs predominantly in black males, while it is rather rare and usually far less severe in Caucasian males.,similarity:Belongs to the intermediate filament family.,subunit:Heterodimer of a type I and a type II keratin (By similarity). May associate with KRT17.,tissue specificity:Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level).,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： intermediate filament,keratin filament,extracellular exosome,
  • 組織表達(dá)： Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level).
  • 科研貨號(hào)： PLA021195
K2C75 rabbit pAb
Catalog No PLA021195
Product information
  • 基因名稱： KRT75 K6HF KB18
  • 蛋白名稱： K2C75
  • Human_gene_id： 9119
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9119
  • Human_swiss_prot_no： O95678
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/O95678/entry
  • Mouse_gene_id： 109052
  • Mouse_gene_link： https://www.uniprot.org/uniprot/109052
  • Mouse_swiss_prot_no： Q8BGZ7
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8BGZ7
  • Rat_gene_id： 300247
  • Rat_gene_link： https://www.uniprot.org/uniprot/300247
  • Rat_swiss_prot_no： Q6IG05
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q6IG05
  • 特異性： This antibody detects endogenous levels of K2C75 at Human/Mouse/Rat
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 分子量： 61kD
  • 功能： disease:Defects in KRT75 may be a cause of loose anagen hair syndrome (LAHS) [MIM:600628]. In LAHS, anagen hairs are easily pulled from the scalp. The hair is relatively sparse and does not grow long. Hair of fair color and hair shafts of reduced caliber, and an early age of onset are features. Usually the hairs are not fragile and there are no areas of breakage.,function:Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle.,miscellaneous:May be used as a marker of hair differentiation.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).,polymorphism:The Thr-161 variant may increase risk to develop pseudofolliculitis barbae (PFB) [MIM:612318]. PFB is a common hair disorder characterized by a pustular foreign body inflammatory reaction that is induced by ingrown hairs of the facial and submental (barbea) regions after regular shaving. It occurs predominantly in black males, while it is rather rare and usually far less severe in Caucasian males.,similarity:Belongs to the intermediate filament family.,subunit:Heterodimer of a type I and a type II keratin (By similarity). May associate with KRT17.,tissue specificity:Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level).,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： intermediate filament,keratin filament,extracellular exosome,
  • 組織表達(dá)： Highly expressed in hair follicles from scalp. Specifically expressed in the of the hair companion layer follicle, a single layered band of flat and vertically oriented cells between the cuboidal outer root sheath (ORS) cells and the inner root sheath (IRS) that stretches from the lowermost bulb region to the isthmus of the follicle. Also expressed in medullated hairs. In nails, it is almost exclusively present in the nail bed (at protein level).
  • 科研貨號(hào)： PLA021195
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