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PIWL4 rabbit pAb
商品貨號： PLA021180
適 應(yīng) 性： 人,小鼠,大鼠
WB IHC
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 基因名稱： PIWIL4 HIWI2 PIWI
  • 蛋白名稱： PIWL4
  • Human_gene_id： 143689
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=143689
  • Human_swiss_prot_no： Q7Z3Z4
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q7Z3Z4/entry
  • Mouse_gene_id： 330890
  • Mouse_gene_link： https://www.uniprot.org/uniprot/330890
  • Mouse_swiss_prot_no： Q8CGT6
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8CGT6
  • Rat_swiss_prot_no： Q4G033
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q4G033
  • 特異性： This antibody detects endogenous levels of PIWL4 at Human/Mouse/Rat
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000;IHC-p 1:50-300
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 分子量： 94kD
  • 功能： function:Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates to a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci.,similarity:Belongs to the argonaute family. Piwi subfamily.,similarity:Contains 1 PAZ domain.,similarity:Contains 1 Piwi domain.,subcellular location:Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. PIWIL2/MILI is required for nuclear localization.,tissue specificity:Expressed in testis. According to PubMed:17544373, it is ubiquitously expressed.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Nucleus . Cytoplasm . Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). .
  • 組織表達： Ubiquitously expressed (PubMed:25038252, PubMed:17544373, PubMed:28025795, PubMed:28711973, PubMed:22483988). Detected in retina, retinal pigment epithelia cells (RPE) (at protein level) (PubMed:28025795).
  • 科研貨號： PLA021180
PIWL4 rabbit pAb
Catalog No PLA021180
Product information
  • 基因名稱： PIWIL4 HIWI2 PIWI
  • 蛋白名稱： PIWL4
  • Human_gene_id： 143689
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=143689
  • Human_swiss_prot_no： Q7Z3Z4
  • Human_swiss_link： https://www.uniprot.org/uniprotkb/Q7Z3Z4/entry
  • Mouse_gene_id： 330890
  • Mouse_gene_link： https://www.uniprot.org/uniprot/330890
  • Mouse_swiss_prot_no： Q8CGT6
  • Mouse_swiss_link： https://www.uniprot.org/uniprotkb/Q8CGT6
  • Rat_swiss_prot_no： Q4G033
  • Rat_swiss_link： https://www.uniprot.org/uniprotkb/Q4G033
  • 特異性： This antibody detects endogenous levels of PIWL4 at Human/Mouse/Rat
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Polyclonal, Rabbit,IgG
  • 稀釋： WB 1:500-2000;IHC-p 1:50-300
  • 純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 分子量： 94kD
  • 功能： function:Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. The piRNA process acts upstream of known mediators of DNA methylation. Participates to a piRNA amplification loop. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). May be involved in the chromatin-modifying pathway by inducing 'Lys-9' methylation of histone H3 at some loci.,similarity:Belongs to the argonaute family. Piwi subfamily.,similarity:Contains 1 PAZ domain.,similarity:Contains 1 Piwi domain.,subcellular location:Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon during meiosis. PIWIL2/MILI is required for nuclear localization.,tissue specificity:Expressed in testis. According to PubMed:17544373, it is ubiquitously expressed.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Nucleus . Cytoplasm . Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). .
  • 組織表達： Ubiquitously expressed (PubMed:25038252, PubMed:17544373, PubMed:28025795, PubMed:28711973, PubMed:22483988). Detected in retina, retinal pigment epithelia cells (RPE) (at protein level) (PubMed:28025795).
  • 科研貨號： PLA021180
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