其他名稱: High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
功能: cell activation,?immune system development,?leukocyte differentiation,?regulation of nucleotide metabolic process,protein amino acid phosphorylation,?phosphorus metabolic process,?phosphate metabolic process,?cell surface receptor linked signal transduction,?enzyme linked receptor protein signaling pathway,?transmembrane receptor protein tyrosine kinase signaling pathway,?activation of adenylate cyclase activity,?intracellular signaling cascade,small GTPase mediated signal transduction,?Ras protein signal transduction,?regulation of cell death,?phosphorylation,hemopoiesis,?lymphocyte differentiation,?neuron differentiation,?B cell differentiation,?regulation of cyclic nucleotide metabolic process,?regulation of cyclic nucleotide biosynthetic process,?regulation of nucleotide biosynthetic process,regulation of cAMP metabolic process,?regulation of cAMP biosynthetic process,?regulation of cyclase activity,?positive regulation of cyclase activity,?B cell activation,?mechanoreceptor differentiation,?regulation of apoptosis,?negative regulation of apoptosis,?regulation of programmed cell death,?negative regulation of programmed cell death,?positive regulation of catalytic activity,?regulation of neuron apoptosis,?negative regulation of neuron apoptosis,?positive regulation of molecular function,?leukocyte activation,?regulation of adenylate cyclase activity,?positive regulation of adenylate cyclase activity,?lymphocyte activation,?hemopoietic or lymphoid organ development,?regulation of lyase activity,?positive regulation of lyase activity,?negative regulation of cell death,
細(xì)胞定位: Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Recycling endosome membrane ; Single-pass type I membrane protein . Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. .
組織表達(dá): Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.
科研貨號(hào): PLA000695
Phospho Trk A (Y701) Cell-Based Colorimetric ELISA Kit
其他名稱: High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
功能: cell activation,?immune system development,?leukocyte differentiation,?regulation of nucleotide metabolic process,protein amino acid phosphorylation,?phosphorus metabolic process,?phosphate metabolic process,?cell surface receptor linked signal transduction,?enzyme linked receptor protein signaling pathway,?transmembrane receptor protein tyrosine kinase signaling pathway,?activation of adenylate cyclase activity,?intracellular signaling cascade,small GTPase mediated signal transduction,?Ras protein signal transduction,?regulation of cell death,?phosphorylation,hemopoiesis,?lymphocyte differentiation,?neuron differentiation,?B cell differentiation,?regulation of cyclic nucleotide metabolic process,?regulation of cyclic nucleotide biosynthetic process,?regulation of nucleotide biosynthetic process,regulation of cAMP metabolic process,?regulation of cAMP biosynthetic process,?regulation of cyclase activity,?positive regulation of cyclase activity,?B cell activation,?mechanoreceptor differentiation,?regulation of apoptosis,?negative regulation of apoptosis,?regulation of programmed cell death,?negative regulation of programmed cell death,?positive regulation of catalytic activity,?regulation of neuron apoptosis,?negative regulation of neuron apoptosis,?positive regulation of molecular function,?leukocyte activation,?regulation of adenylate cyclase activity,?positive regulation of adenylate cyclase activity,?lymphocyte activation,?hemopoietic or lymphoid organ development,?regulation of lyase activity,?positive regulation of lyase activity,?negative regulation of cell death,
細(xì)胞定位: Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Recycling endosome membrane ; Single-pass type I membrane protein . Rapidly internalized after NGF binding (PubMed:1281417). Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes. .
組織表達(dá): Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors.