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Phospho PDK1 (S241) Cell-Based Colorimetric ELISA Kit
商品貨號(hào)： PLA000639
適 應(yīng) 性： 人,小鼠,大鼠
ELISA
￥600元
規(guī)格：
在線咨詢
MSDS
說(shuō)明書
商品描述
  • 發(fā)貨日期： 14
  • 基因名稱： PDPK1
  • Human_gene_id： 5170
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5170
  • Human_swiss_prot_no： O15530
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/O15530/entry
  • Mouse_swiss_prot_no： Q9Z2A0
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z2A0
  • Rat_swiss_prot_no： O55173
  • Rat_swiss_link： http://www.uniprot.org/uniprot/O54941O55173
  • 儲(chǔ)存： 2-8°C/6 months
  • 說(shuō)明書： KA1637C.pdf
  • 其他名稱： 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
  • 功能： protein amino acid phosphorylation,?negative regulation of protein kinase activity,?phosphorus metabolic process,phosphate metabolic process,?response to osmotic stress,?hyperosmotic response,?cytoskeleton organization,?cell-substrate junction assembly,?cell adhesion,?cell-matrix adhesion,?intracellular signaling cascade,?response to abiotic stimulus,?response to endogenous stimulus,?response to hormone stimulus,?response to organic substance,phosphorylation,?peptidyl-threonine phosphorylation,?peptidyl-threonine modification,?regulation of phosphate metabolic process,?biological adhesion,?actin filament-based process,?actin cytoskeleton organization,?cell-substrate adhesion,?activation of protein kinase activity,?activation of protein kinase B activity,?response to insulin stimulus,cellular response to insulin stimulus,?cellular response to hormone stimulus,?regulation of protein localization,?negative regulation of kinase activity,?positive regulation of kinase activity,?cell junction assembly,?cell junction organization,regulation of phosphorylation,?positive regulation of catalytic activity,?negative regulation of catalytic activity,?response to peptide hormone stimulus,?regulation of kinase activity,?negative regulation of molecular function,?positive regulation of molecular function,?regulation of protein kinase activity,?positive regulation of protein kinase activity,?focal adhesion formation,?positive regulation of cellular component organization,?regulation of phosphorus metabolic process,?regulation of transferase activity,?positive regulation of transferase activity,?negative regulation of transferase activity,?regulation of establishment of protein localization,?regulation of establishment of protein localization to plasma membrane,?positive regulation of establishment of protein localization to plasma membrane,
  • 相關(guān)產(chǎn)品： YT3645,YT3643,YP1032,YP0222,KA4227C,KA1637C
  • 細(xì)胞定位： Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation.
  • 組織表達(dá)： Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast.
  • 科研貨號(hào)： PLA000639
Phospho PDK1 (S241) Cell-Based Colorimetric ELISA Kit
Catalog No PLA000639
Product information
  • 發(fā)貨日期： 14
  • 基因名稱： PDPK1
  • Human_gene_id： 5170
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5170
  • Human_swiss_prot_no： O15530
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/O15530/entry
  • Mouse_swiss_prot_no： Q9Z2A0
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9Z2A0
  • Rat_swiss_prot_no： O55173
  • Rat_swiss_link： http://www.uniprot.org/uniprot/O54941O55173
  • 儲(chǔ)存： 2-8°C/6 months
  • 說(shuō)明書： KA1637C.pdf
  • 其他名稱： 3-phosphoinositide-dependent protein kinase 1 (hPDK1) (EC 2.7.11.1)
  • 功能： protein amino acid phosphorylation,?negative regulation of protein kinase activity,?phosphorus metabolic process,phosphate metabolic process,?response to osmotic stress,?hyperosmotic response,?cytoskeleton organization,?cell-substrate junction assembly,?cell adhesion,?cell-matrix adhesion,?intracellular signaling cascade,?response to abiotic stimulus,?response to endogenous stimulus,?response to hormone stimulus,?response to organic substance,phosphorylation,?peptidyl-threonine phosphorylation,?peptidyl-threonine modification,?regulation of phosphate metabolic process,?biological adhesion,?actin filament-based process,?actin cytoskeleton organization,?cell-substrate adhesion,?activation of protein kinase activity,?activation of protein kinase B activity,?response to insulin stimulus,cellular response to insulin stimulus,?cellular response to hormone stimulus,?regulation of protein localization,?negative regulation of kinase activity,?positive regulation of kinase activity,?cell junction assembly,?cell junction organization,regulation of phosphorylation,?positive regulation of catalytic activity,?negative regulation of catalytic activity,?response to peptide hormone stimulus,?regulation of kinase activity,?negative regulation of molecular function,?positive regulation of molecular function,?regulation of protein kinase activity,?positive regulation of protein kinase activity,?focal adhesion formation,?positive regulation of cellular component organization,?regulation of phosphorus metabolic process,?regulation of transferase activity,?positive regulation of transferase activity,?negative regulation of transferase activity,?regulation of establishment of protein localization,?regulation of establishment of protein localization to plasma membrane,?positive regulation of establishment of protein localization to plasma membrane,
  • 相關(guān)產(chǎn)品： YT3645,YT3643,YP1032,YP0222,KA4227C,KA1637C
  • 細(xì)胞定位： Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non-neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation.
  • 組織表達(dá)： Appears to be expressed ubiquitously. The Tyr-9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast.
  • 科研貨號(hào)： PLA000639
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